Validated spectrophotometric methods for the determination of Tadalafil in pharmaceutical formulations
نویسنده
چکیده
Two simple and sensitive UV-Visible spectrophotometric methods A and B for the determination of tadalafil have been described. These methods are based on the formation of bluish green color and blue colored chromogens obtained when the drug was condensed with Isatin and Xanthydrol exhibiting λmax at 665 and 640nm respectively. These methods obey Beer’s Law in the concentration ranges of 0.4-2.0 and 4-20 μg/mL. The optimum conditions for all color development are described and the proposed methods have been successfully applied for the determination of tadalafil in bulk drug and pharmaceutical formulations. The common execipients and additives did not interfere in this method.
منابع مشابه
Adaptive neuro-fuzzy inference system (ANFIS) applied for spectrophotometric determination of fluoxetine and sertraline in pharmaceutical formulations and biological fluid
The UV-spectrophotometric method of analysis was proposed for simultaneous determination of fluoxetine (FLX) and sertraline (SRT). Considering the strong spectral overlap between UV-Vis spectra of these compounds, a previous separation should be carried out in order to determine them by conventional spectrophotometric techniques. Here, full-spectrum multivariate calibrations adaptive neuro-fuzz...
متن کاملPartial Least Square and Parallel Factor Analysis Methods Applied for Spectrophotometric Determination of Cefixime in Pharmaceutical Formulations and Biological Fluid
In this study, the direct determination of cefixime as an anti-bacterial agent, in pharmaceutical formulations, urine and human blood plasma was conducted based on spectrophotometric measurements using parallel factor analysis (PARAFAC) and partial least squares (PLS). The calibration set was composed of fourteen solutions in the range of 0.50- 9.00 µg mL-1. PLS models were calculated at each p...
متن کاملPartial Least Square and Parallel Factor Analysis Methods Applied for Spectrophotometric Determination of Cefixime in Pharmaceutical Formulations and Biological Fluid
In this study, the direct determination of cefixime as an anti-bacterial agent, in pharmaceutical formulations, urine and human blood plasma was conducted based on spectrophotometric measurements using parallel factor analysis (PARAFAC) and partial least squares (PLS). The calibration set was composed of fourteen solutions in the range of 0.50- 9.00 µg mL-1. PLS models were calculated at each p...
متن کاملSelective Cloud Point Extraction for the Spectrophotometric Determination of Cetylpyridinium Chloride in Pharmaceutical Formulations
In this work, we developed a simple and selective method for separation and spectrophotometric determination of trace amounts of cetylpyridinium chloride (CPC) in pharmaceutical products using cloud point extraction (CPE) technique. The method is based on cloud point extraction of the CPC in alkali conditions using of nonionic surfactant Triton X-114. Under selected conditions, the calibration ...
متن کاملArtificial Neural Networks (ANN) for the simultaneous spectrophotometric determination of fluoxetine and sertraline in pharmaceutical formulations and biological fluid
Simultaneous spectrophotometric estimation of Fluoxetine and Sertraline in tablets were performed using UV–Vis spectroscopic and Artificial Neural Networks (ANN). Absorption spectra of two components were recorded in 200–300 (nm) wavelengths region with an interval of 1 nm. The calibration models were thoroughly evaluated at several concentration levels using the spectra of synthetic binary mix...
متن کامل